The Parts of its Sum
What goes into a Polypill?
Trials in Australia and New Zealand will test two polypill types and six dosage combinations. Here's a breakdown of one formulation.
Dosage:10, 20, or 40 mg
Function:Lowers cholesterol by inhibiting the enzyme HMG-Coa reductase
Benefit:May reduce heart disease risk by at least 25%
Side Effects:Rare instances of rhabdomyolysis and liver failure
Names:Lisinopril & Hydrochlorothiazide
Dosage:5 or 10 mg & 12.5 mg
Function:Lisinopril blocks angiotensin in the kidneys, promoting excretion of water and salt. Hydrochlorothiazide is a diuretic that blocks the kidneys from absorbing sodium
Benefit:Together, may reduce heart attack risk by 15-20%, stroke risk by 40-50%
Side Effects:Among other effects, adverse levels of potassium and other substances in the blood
Function:Prevents platelets from forming into clots
Benefit:Reduces ischemic heart disease events by32% and strokes by 16%
Side Effects:poses the most serious risks because of hemorrage